	US 12,343,409 B1
	Radiopharmaceutical composition and methods
Manuel Sturzbecher-Höhne, Berlin (DE); Dennis Mewis, Berlin (DE); and Marion Huber, Berlin (DE)
Assigned to Ariceum Therapeutics GmbH, Berlin (DE)
Filed by Ariceum Therapeutics GmbH, Berlin (DE)
Filed on Jul. 11, 2024, as Appl. No. 18/770,529.
Claims priority of application No. 24180333 (EP), filed on Jun. 5, 2024.
Int. Cl. A61K 51/04 (2006.01); A61K 47/22 (2006.01)

CPC A61K 51/0482 (2013.01) [A61K 47/22 (2013.01)]

11 Claims

1. A method of preparing a liquid radiopharmaceutical composition comprising a radiopharmaceutical compound according to Formula I

or a pharmaceutically acceptable salt thereof,

the method comprising:

providing a liquid radiopharmaceutical pre-composition comprising:

i. a precursor compound according to Formula II

or a pharmaceutically acceptable salt thereof;

ii. a buffer, wherein the buffer provides the liquid radiopharmaceutical pre-composition with a pH of about 8.0 to about 8.9; and

iii. a [²²⁵Ac]Ac³⁺ salt;

heating the liquid radiopharmaceutical pre-composition to generate a labelled composition;

cooling the labelled composition; and

diluting the labelled composition with a formulation solution; wherein the formulation solution comprises a formulation buffer that provides the liquid radiopharmaceutical composition with a pH of about 8.0 to about 8.9.