US 12,343,386 B2
Compositions for remodeling extracellular matrix and methods of use thereof
Irit Sagi, Rehovot (IL); Inna Solomonov, Rishon LeZion (IL); and Eldar Zehorai, Tel-Aviv (IL)
Assigned to NanoCell Ltd., Rehovot (IL)
Filed by NanoCell Ltd., Rehovot (IL)
Filed on Oct. 9, 2023, as Appl. No. 18/377,890.
Application 18/377,890 is a continuation of application No. 17/859,005, filed on Jul. 7, 2022, granted, now 11,779,636.
Application 17/859,005 is a continuation of application No. 16/903,402, filed on Jun. 17, 2020, granted, now 11,382,959, issued on Jul. 12, 2022.
Application 16/903,402 is a continuation of application No. 15/563,994, granted, now 10,722,560, issued on Jul. 28, 2020, previously published as PCT/IB2016/000526, filed on Apr. 1, 2016.
Claims priority of provisional application 62/142,675, filed on Apr. 3, 2015.
Claims priority of provisional application 62/142,661, filed on Apr. 3, 2015.
Claims priority of provisional application 62/142,672, filed on Apr. 3, 2015.
Prior Publication US 2024/0041992 A1, Feb. 8, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/48 (2006.01); A61B 17/435 (2006.01); A61D 19/04 (2006.01); A61K 9/00 (2006.01); A61K 38/46 (2006.01); A61P 15/00 (2006.01)
CPC A61K 38/4886 (2013.01) [A61B 17/435 (2013.01); A61D 19/04 (2013.01); A61K 9/0034 (2013.01); A61K 38/46 (2013.01); A61P 15/00 (2018.01); C12Y 304/24 (2013.01); C12Y 304/24007 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method of increasing rate of embryo implantation in a uterus of a mammal, the method comprising:
a. administering in an intrauterine manner at least one extra cellular matrix (ECM) remodeling enzyme selected from the group consisting of matrix metalloproteinase (MMP)-1 and MMP-13 to the uterus of the mammal; and
b. introducing at least one embryo into the uterus, wherein steps (a) and (b) are performed concurrently, thereby increasing rate of embryo implantation.