US 12,343,338 B2
Ramipril solution for oral dosage
Sandip Mehta, Ahmedabad (IN); Manish Kumar Umrethia, Ahmedabad (IN); and Jayanta Mandal, Ahmedabad (IN)
Assigned to LIQMEDS WORLDWIDE LIMITED, Northampton (GB)
Filed by LIQMEDS WORLDWIDE LIMITED, Weedon (GB)
Filed on May 2, 2024, as Appl. No. 18/652,993.
Application 18/652,993 is a continuation of application No. 18/311,126, filed on May 2, 2023, granted, now 12,016,857.
Application 18/311,126 is a continuation of application No. 17/299,844, granted, now 11,738,020, issued on Aug. 29, 2023, previously published as PCT/IB2019/000979, filed on Aug. 16, 2019.
Claims priority of application No. 201821030979 (IN), filed on Aug. 18, 2018.
Prior Publication US 2024/0293393 A1, Sep. 5, 2024
Int. Cl. A61K 31/4725 (2006.01); A61K 31/197 (2006.01); A61K 31/403 (2006.01); A61K 31/4045 (2006.01); A61K 47/12 (2006.01)
CPC A61K 31/4725 (2013.01) [A61K 31/197 (2013.01); A61K 31/403 (2013.01); A61K 31/4045 (2013.01); A61K 47/12 (2013.01)] 16 Claims
 
1. A liquid pharmaceutical solution, consisting of:
an active pharmaceutical ingredient consisting of ramipril or a pharmaceutically acceptable salt thereof in an amount of about 0.1% wt;
an antimicrobial preservative selected from the group consisting of methylparaben, ethylparaben, and a combination thereof in an amount of from about 0.1% wt to about 1% wt;
a buffering agent selected from the group consisting of citric acid, citric acid monohydrate, and a combination thereof;
a sweetener;
a flavoring agent; and
water;
wherein the liquid pharmaceutical solution has a pH of from about 3 to about 4; and
wherein the liquid pharmaceutical solution does not contain a polyhydric alcohol having 2 to 6 carbon atoms.