US 12,343,334 B2
Compositions and methods for treating severe constipation
Brian K. Hubbard, Boxford, MA (US); and Michael H. Serrano-Wu, Belmont, MA (US)
Assigned to Serleva, Inc., Short Hills, NJ (US)
Filed by Serleva, Inc., Short Hills, NJ (US)
Filed on Oct. 11, 2023, as Appl. No. 18/378,976.
Application 18/378,976 is a continuation of application No. 17/565,584, filed on Dec. 30, 2021, granted, now 11,819,495.
Application 17/565,584 is a continuation of application No. 16/355,085, filed on Mar. 15, 2019, granted, now 11,224,590.
Claims priority of provisional application 62/644,033, filed on Mar. 16, 2018.
Prior Publication US 2024/0293376 A1, Sep. 5, 2024
Int. Cl. A61P 1/10 (2006.01); A61K 31/4245 (2006.01); A61K 31/444 (2006.01)
CPC A61K 31/4245 (2013.01) [A61K 31/444 (2013.01); A61P 1/10 (2018.01)] 5 Claims
 
1. A method of treating constipation in a subject in need thereof, the method comprising administering to the subject a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor, wherein the DGAT1 inhibitor is trans-4-(4-(5-((6-(trifluoromethyl) pyridin-3-yl)amino)pyridin-2-yl)phenyl)cyclohexane acetic acid (pradigastat) or a pharmaceutically acceptable salt or ester thereof;
wherein the constipation is irritable bowel syndrome with constipation, or constipation due to pregnancy, medications, or a neurological disorder.