	US 12,343,329 B2
	Method for suppressing production of asenapine-N-oxide
Yuka Takagi, Tsukuba (JP); and Masaki Yukuhiro, Tsukuba (JP)
Assigned to HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
Appl. No. 17/768,555
Filed by HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
PCT Filed Oct. 19, 2020, PCT No. PCT/JP2020/039240 § 371(c)(1), (2) Date Apr. 13, 2022, PCT Pub. No. WO2021/085211, PCT Pub. Date May 6, 2021.
Claims priority of application No. 2019-195125 (JP), filed on Oct. 28, 2019; and application No. 2020-063702 (JP), filed on Mar. 31, 2020.
Prior Publication US 2024/0122898 A1, Apr. 18, 2024
Int. Cl. A61K 31/407 (2006.01); A61K 9/70 (2006.01); A61K 47/02 (2006.01)

CPC A61K 31/407 (2013.01) [A61K 9/7053 (2013.01); A61K 47/02 (2013.01)]

3 Claims

1. A patch comprising an adhesive layer on a backing, the adhesive layer comprising:

3 to 10% by mass relative to the total mass of the adhesive layer of asenapine or a pharmaceutically acceptable salt thereof;

an adhesive base; and

0.02 to 1% by mass relative to the total mass of the adhesive layer of at least one component selected from the group consisting of thiosulfates, sulfites, and pyrosulfites;

wherein the adhesive base is a rubber-based adhesive base consisting of a styrene-isoprene-styrene block copolymer and polyisobutylene.