	US 12,343,321 B1
	Method for ameliorating or avoiding the adverse effects of exogenous gonadotropins on reproductive performance
Jianhui Tian, Beijing (CN); Shumin Wang, Beijing (CN); Lei An, Beijing (CN); Yue Wang, Beijing (CN); Yusheng Qin, Beijing (CN); and Wei Zhao, Beijing (CN)
Assigned to CHINA AGRICULTURAL UNIVERSITY, Beijing (CN)
Filed by CHINA AGRICULTURAL UNIVERSITY, Beijing (CN)
Filed on Sep. 27, 2024, as Appl. No. 18/899,511.
Claims priority of application No. 202410578838.2 (CN), filed on May 10, 2024.
Int. Cl. A61K 31/197 (2006.01); A61K 9/00 (2006.01); A61K 31/07 (2006.01); A61K 31/575 (2006.01); A61K 38/09 (2006.01); A61K 45/06 (2006.01)

CPC A61K 31/197 (2013.01) [A61K 9/0056 (2013.01); A61K 31/07 (2013.01); A61K 31/575 (2013.01); A61K 38/09 (2013.01); A61K 45/06 (2013.01)]

6 Claims

1. A husbandry method for ameliorating or avoiding the effect of exogenous gonadotropins on reproductive performance of female animals comprising:

feeding a composition having active ingredients consisting of only N-acetylcysteine and vitamin A to the female animals prior to the treatment with the exogenous gonadotropins;

after feeding the composition, an ERα-FGF-pERK-cell cycle signaling pathway of the female animals is inhibited to improve uterine receptivity and a pregnancy outcome by the exogenous gonadotropin treatment; and

the mass ratio of the N-acetylcysteine to the vitamin A is 0.5:1 to 2:1, and the dose of the vitamin A is 60 mg/kg BW/day to 120 mg/kg BW/day,

wherein the female animal is selected from a gilt or a sow.