| CPC A61F 2/2418 (2013.01) [A61F 2/2412 (2013.01); A61L 27/24 (2013.01); A61L 27/3625 (2013.01); A61L 27/3629 (2013.01); A61L 27/3641 (2013.01); A61L 27/3687 (2013.01); A61L 27/3834 (2013.01); A61F 2/2457 (2013.01); A61F 2220/0008 (2013.01); A61L 2300/222 (2013.01); A61L 2300/426 (2013.01); A61L 2400/16 (2013.01); A61L 2430/20 (2013.01)] | 17 Claims |
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1. A prosthetic valve for modulating fluid flow through a cardiovascular structure during cardiac cycles of a heart, comprising:
a base valve structure and an expandable stent structure,
said base valve structure comprising collagenous tissue derived from a first mammalian tissue source,
said base valve structure further comprising an internal region, an open proximal valve annulus engagement end and a distal valve structure end, said open proximal valve annulus engagement end being configured and adapted to engage a heart valve annulus, receive said fluid flow therein and direct said fluid flow into said internal region of said base valve structure,
said base valve structure further comprising a plurality of elongated ribbon members that extend from said open proximal valve annulus engagement end to said distal valve structure end, each of said plurality of elongated ribbon members comprising first and second edge regions and proximal and distal ends, said plurality of elongated ribbon members being positioned circumferentially about said base valve structure, wherein said first edge regions of said plurality of elongated ribbon members are positioned proximate said second edge regions of said plurality of elongated ribbon members and form a plurality of flow modulating regions,
said distal ends of said plurality of elongated ribbon members being positioned proximate each other in a constrained relationship, wherein said fluid flow through said distal ends of said plurality of elongated ribbon members and, thereby, said base valve structure is restricted,
said plurality of elongated ribbon members being configured and adapted to deflect outwardly when said open proximal valve annulus engagement end of said base valve structure directs said fluid flow into said internal region of said base valve structure and said fluid flow comprises a positive fluid pressure, whereby a first pressure differential between first valvular pressure in said internal region of said base valve structure relative to first external pressure exerted on said base valve structure is generated, wherein each of said plurality of flow modulating regions transitions from a restricted fluid flow configuration to an open fluid flow configuration and allows said fluid flow to be transmitted through said plurality of flow modulating regions and, thereby, through and out of said base valve structure,
said plurality of elongated ribbon members being further configured and adapted to deflect inwardly when said first pressure differential transitions to a second pressure differential between second valvular pressure in said internal region of said base valve structure relative to second external pressure exerted on said base valve structure, said second pressure differential being lower than said first pressure differential, wherein each of said plurality of flow modulating regions transitions from said open fluid flow configuration to said restricted fluid flow configuration and restricts said fluid flow through said plurality of flow modulating regions and, thereby, through and out of said base valve structure,
said expandable stent structure being positioned in said internal region of said base valve structure,
said expandable stent structure comprising a plurality of tethers adapted to pierce cardiovascular tissue and, thereby, position said base valve structure on said heart valve annulus,
wherein said stent structure comprises a shape-memory alloy, and
wherein said prosthetic valve is adapted to evert to an everted configuration.
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