US 12,343,238 B2
Wound dressing comprising a combination of hydrogel and honey, method of preparation and uses thereof
Daniel Lev, Western Galilee (IL); and Yulia Holenberg, Ramat Hagolan (IL)
Assigned to Sion Biotext Medical Ltd., Sderot (IL)
Appl. No. 17/777,955
Filed by Sion Biotext Medical Ltd., Sderot (IL)
PCT Filed Nov. 19, 2020, PCT No. PCT/IL2020/051200
§ 371(c)(1), (2) Date May 18, 2022,
PCT Pub. No. WO2021/100045, PCT Pub. Date May 27, 2021.
Claims priority of application No. 270762 (IL), filed on Nov. 19, 2019.
Prior Publication US 2023/0032299 A1, Feb. 2, 2023
Int. Cl. A61F 13/00 (2024.01); A61F 13/01 (2024.01); A61K 35/644 (2015.01); A61L 15/40 (2006.01); A61L 15/44 (2006.01); A61L 26/00 (2006.01)
CPC A61F 13/00063 (2013.01) [A61F 13/01008 (2024.01); A61K 35/644 (2013.01); A61L 15/40 (2013.01); A61L 15/44 (2013.01); A61L 26/0009 (2013.01); A61L 26/008 (2013.01); A61F 2013/00161 (2013.01); A61L 2300/404 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A wound dressing composition comprising cross-linked hydrogel scaffold and embedded therein anti-bacterially active honey:
wherein the wound dressing composition has an anti-bacterial activity that is determined by a detection of hydrogen peroxide production rate by the wound dressing composition;
wherein the wound dressing composition further comprising at least one photo-initiator and at least one UV cross linker;
wherein a total amount of the at least one photo-initiator and the at least one UV cross linker is equal or less than 0.2% w/w out of a total weight of the wound dressing composition;
wherein an amount of the at least one UV cross linker does not exceed 0.15% w/w out of the total weight of the wound dressing composition; and
wherein the amount of the at least one photo-initiator and the at least one UV cross linker is effective to provide the wound dressing composition with no detectable amount of free monomer units.
 
11. A method of producing a wound dressing composition comprising cross-linked hydrogel scaffold and embedded therein anti-bacterially active honey, the method comprises:
mixing a hydrogel forming mixture comprising hydrogel forming monomer or monomers, anti-bacterially active honey, at least one photo-initiator and at least one UV cross linker to form a homogenous mixture; and
subjecting the homogenous mixture to UV irradiation until the homogenous mixture solidifies;
wherein a total amount of the at least one photo-initiator and the at least one UV cross linker is equal or less than 0.2% w/w out of a total weight of the wound dressing composition;
wherein an amount of the at least one UV cross linker does not exceed 0.15% w/w out of the total weight of the wound dressing composition; and
wherein the amount of the at least one photo-initiator and the at least one UV cross linker is effective to allow complete cross-linking of monomers of the cross-linked hydrogel.