| CPC A61B 5/24 (2021.01) [A61B 5/7217 (2013.01); A61N 1/36125 (2013.01); A61N 1/36142 (2013.01); A61B 5/30 (2021.01)] | 8 Claims |

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1. A method for controlling electrical conditions of tissue in relation to a current stimulus, the method comprising:
delivering to the tissue via a current injection electrode a first stimulus current produced by a first current source;
extracting from the tissue via a current extraction electrode a second stimulus current drawn by a second current source, wherein:
the current injection electrode and the current extraction electrode form a dipole;
the current stimulus comprises the first stimulus current and the second stimulus current; and
the second stimulus current differs from the first stimulus current by a mismatch current;
extracting from the tissue, via a ground electrode connected to an electrical ground, the mismatch current; and
measuring via at least one measurement electrode a response of the tissue to the current stimulus, wherein the at least one measurement electrode is located outside the dipole formed by the current injection electrode and the current extraction electrode, and
wherein the ground electrode is interposed between:
the dipole formed by the current injection electrode and the current extraction electrode, and
the at least one measurement electrode.
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