| CPC A61B 5/14532 (2013.01) [A61B 5/14503 (2013.01); A61B 5/14546 (2013.01); A61B 5/7203 (2013.01); A61B 5/7235 (2013.01); A61B 5/7275 (2013.01); G16H 50/20 (2018.01); A61B 2560/0475 (2013.01); G06F 2218/10 (2023.01)] | 23 Claims |

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1. A method for lag correction of data from a glucose sensor, comprising:
defining a scaling factor for lag correction;
receiving glucose data from the glucose sensor, the sensor data including historical glucose sensor data over a plurality of intervals;
defining a probability density function of the glucose data over at least a portion of one of the plurality of intervals;
determining a value of the scaling factor based on the probability density function and a normalized analyte variability ratio, wherein the value of the scaling factor is computed based on (1) a historic glucose-based, predicted low glucose value corresponding to the probability density function, (2) a first normalized glucose variability, and (3) a second normalized glucose variability; and
computing lag corrected values based on the determined value of the scaling factor.
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