US 12,343,110 B2
Multi-modal imaging device
Shuhua Yue, Beijing (CN); Xun Chen, Beijing (CN); and Pu Wang, Beijing (CN)
Assigned to BEIHANG UNIVERSITY, Beijing (CN); and SUZHOU SURGI-MASTER HIGH TECH CO., LTD., Jiangsu (CN)
Filed by BEIHANG UNIVERSITY, Beijing (CN); and SUZHOU SURGI-MASTER HIGH TECH CO., LTD., Jiangsu (CN)
Filed on May 22, 2024, as Appl. No. 18/670,811.
Application 18/670,811 is a continuation of application No. PCT/CN2022/129956, filed on Nov. 4, 2022.
Claims priority of application No. 202111381679.X (CN), filed on Nov. 22, 2021.
Prior Publication US 2024/0306913 A1, Sep. 19, 2024
Int. Cl. A61B 5/00 (2006.01)
CPC A61B 5/0035 (2013.01) [A61B 5/0066 (2013.01); A61B 5/0075 (2013.01); A61B 5/0084 (2013.01); A61B 5/6847 (2013.01); A61B 2560/0462 (2013.01); A61B 2562/0233 (2013.01); A61B 2576/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A multi-modal imaging device, comprising:
a Raman spectroscopic analysis module configured to obtain Raman spectroscopic information of a target object on a first sampling position by using excitation light;
an optical coherence tomography module configured to obtain a tissue structure image of the target object on a second sampling position by using imaging detection light; and
a co-localization module configured to control the first sampling position of the excitation light in the Raman spectroscopic analysis module according to a determined concerned area of the target object, so that the first sampling position and the second sampling position are spatially co-localized in the determined concerned area;
an image processing module configured to fuse the Raman spectroscopic information of the first sampling position and the tissue structure image of the second sampling position, which are spatially co-localized, so as to generate fused multi-modal information of the determined concerned area;
wherein spatial co-localization means that the Raman spectroscopic information from the Raman spectroscopic analysis module and tissue structure image information from the optical coherence tomography module are from a same spatial position,
wherein the co-localization module is arranged in an incident light path of the excitation light from the Raman spectroscopic analysis module, wherein the multi-modal imaging device comprises a probe provided with a shell and a detection window and configured to detect the target object, and the excitation light from the Raman spectroscopic analysis module and the imaging detection light from the optical coherence tomography module are coupled in the probe,
wherein the Raman spectroscopic analysis module comprises a first light source, a first beam splitting mirror, a first coupling objective lens, a first optical fiber, a spectrometer, a first lens group, and a first dichroscope; and
the first beam splitting mirror is configured to transmit excitation light from the first light source and reflect Raman spectroscopy scattering signal light from the target object, the spectrometer is configured to receive the Raman spectroscopy scattering signal light from the target object reflected by the first beam splitting mirror, the first coupling objective lens is configured to receive emergent light from the co-localization module, the first optical fiber is configured to receive emergent light from the first coupling objective lens, the first lens group is configured to receive emergent light from the first optical fiber, and the first dichroscope is configured to receive and transmit emergent light from the first lens group, wherein the first lens group comprises a collective lens.