US 12,343,071 B2
Voltage controlled pulse sequences for irreversible electroporation ablations
Nathaniel Adams, New Richmond, WI (US); Jonathan Tyler Gorzycki, Blaine, MN (US); Randall Dodson, New Hope, MN (US); and Brendan Early Koop, Ham Lake, MN (US)
Assigned to Boston Scientific Scimed, Inc, Maple Grove, MN (US)
Filed by Boston Scientific Scimed Inc, Maple Grove, MN (US)
Filed on Jan. 24, 2022, as Appl. No. 17/582,733.
Claims priority of provisional application 63/142,133, filed on Jan. 27, 2021.
Prior Publication US 2022/0233237 A1, Jul. 28, 2022
Int. Cl. A61B 18/00 (2006.01); A61B 18/12 (2006.01); A61B 18/14 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 18/1206 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00767 (2013.01); A61B 2018/00827 (2013.01); A61B 2018/00875 (2013.01); A61B 2018/00892 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An electroporation ablation system for treating targeted tissue in a patient, the electroporation ablation system comprising:
an ablation catheter including:
catheter electrodes configured to generate electric fields in the targeted tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections;
a controller configured to:
receive a first pulse voltage of a first electrical pulse sequence measured during a first therapy section of the plurality of therapy sections;
determine a charge voltage based on the first pulse voltage; and
an electroporation generator operatively coupled to the catheter electrodes and the controller and configured to deliver a second electrical pulse sequence at a controlled pulse voltage for a second therapy section of the plurality of therapy sections, the second therapy section being after the first therapy section, the controlled pulse voltage being associated with the charge voltage
wherein the electroporation generator is further configured to deliver a scan electrical pulse sequence at a scan voltage during a scan section prior to the plurality of therapy sections; and
wherein the controller is further configured to determine an initial tissue impedance based on an initial pulse voltage of the scan electrical pulse sequence and an initial pulse current of the scan electrical pulse sequence measured during the scan section, and determine an initial charge voltage based on the initial tissue impedance.