US 12,019,056 B2
Diagnosis of tuberculosis and other diseases using exhaled breath
Dapeng Chen, Sykesville, MD (US); Wayne A. Bryden, Sykesville, MD (US); and Michael McLoughlin, Sykesville, MD (US)
Assigned to Zeteo Tech, Inc., Sykesville, MD (US)
Filed by Zeteo Tech, Inc., Sykesville, MD (US)
Filed on Oct. 12, 2021, as Appl. No. 17/499,848.
Application 17/499,848 is a continuation in part of application No. PCT/US2020/048040, filed on Aug. 26, 2020.
Claims priority of provisional application 63/069,120, filed on Aug. 23, 2020.
Claims priority of provisional application 62/891,954, filed on Aug. 26, 2019.
Prior Publication US 2022/0034854 A1, Feb. 3, 2022
Int. Cl. G01N 33/497 (2006.01); A61B 5/08 (2006.01); A61B 5/091 (2006.01); A61B 5/097 (2006.01); A61B 10/00 (2006.01); G01N 30/72 (2006.01); A61B 5/087 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/7206 (2013.01) [A61B 5/082 (2013.01); A61B 5/091 (2013.01); A61B 5/097 (2013.01); A61B 10/0045 (2013.01); G01N 33/497 (2013.01); A61B 5/087 (2013.01); A61B 2010/0087 (2013.01); A61B 2562/029 (2013.01); G01N 2030/025 (2013.01); G01N 2800/12 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A system for diagnosing respiratory diseases in an individual using exhaled breath, the system comprising:
a sample extraction component configured to receive an individual's face for extracting breath aerosol (EBA) particles expelled from the individual during a predetermined number of breath maneuvers into a flow of air fed into the sample extraction component;
a sample capture component:
fluidly connected to the sample extraction component and configured to collect the EBA particles into a collected liquid sample;
a packed bed column disposed downstream of the sample capture component and configured to selectively capture the EBA particles from the collected liquid sample onto the packed bed;
means to elute the collected EBA particles from the packed bed using one or more solvents; and
a diagnostic device for analyzing the EBA particles in the one or more solvents.