US 12,019,018 B2
Full-field brillouin microscopy systems and methods
Giuliano Scarcelli, Washington, DC (US); Romanus Hutchins, College Park, MD (US); and Giulia Zanini, University Park, MD (US)
Assigned to UNIVERSITY OF MARYLAND, COLLEGE PARK, College Park, MD (US)
Filed by UNIVERSITY OF MARYLAND, COLLEGE PARK, College Park, MD (US)
Filed on Aug. 4, 2021, as Appl. No. 17/393,532.
Claims priority of provisional application 63/061,104, filed on Aug. 4, 2020.
Prior Publication US 2022/0042908 A1, Feb. 10, 2022
Int. Cl. G01N 21/63 (2006.01); G02B 21/36 (2006.01); G02B 21/04 (2006.01)
CPC G01N 21/636 (2013.01) [G02B 21/361 (2013.01); G01N 2021/638 (2013.01); G02B 21/04 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A full-field microscopy method for detection of Brillouin-scattered light, comprising:
(a) illuminating a two-dimensional plane in a sample with interrogating light having a first wavelength;
(b) collecting light emitted from the two-dimensional plane illuminated by the interrogating light, the emitted light comprising Brillouin-scattered light resulting from interaction of the interrogating light with the sample, the Brillouin-scattered light having a second wavelength shifted from the first wavelength;
(c) passing the collected light through a spectrally-selective assembly comprising a gas or vapor illuminated by pumping light; and
(d) detecting, using an electro-optical sensor, light from the spectrally-selective assembly,
wherein the Brillouin-scattered light from multiple points in the two-dimensional plane in the sample is simultaneously detected by the detecting of (d).