US 12,018,261 B2
Compounds and methods for modulating factor XII
Huynh-Hoa Bui, San Diego, CA (US); Chenguang Zhao, San Diego, CA (US); and Jeffrey R. Crosby, Carlsbad, CA (US)
Assigned to Ionis Pharmaceuticals, Inc., Carlsbad, CA (US)
Filed by Ionis Pharmaceuticals, Inc., Carlsbad, CA (US)
Filed on Dec. 17, 2021, as Appl. No. 17/554,920.
Claims priority of provisional application 63/127,616, filed on Dec. 18, 2020.
Prior Publication US 2023/0002771 A1, Jan. 5, 2023
Int. Cl. C12N 15/113 (2010.01)
CPC C12N 15/1137 (2013.01) [C12N 2310/14 (2013.01); C12N 2310/31 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/341 (2013.01); C12N 2310/346 (2013.01)] 58 Claims
 
1. An oligomeric compound according to the following chemical structure:

OG Complex Work Unit Chemistry
(SEQ ID NO: 3379), or a salt thereof.