CPC C12N 15/113 (2013.01) [A61K 31/702 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3515 (2013.01)] | 19 Claims |
1. A modified oligonucleotide comprising 8-15 linked nucleotides, wherein at most only three of the nucleotides are high affinity monomers, and wherein the modified oligonucleotide comprises a nucleotide sequence substantially complementary to positions 2-8 of an antisense strand of an siRNA, and one of the high affinity monomers in the modified oligonucleotide is base paired with the 6th nucleotide from the 5′-end of the antisense strand of the siRNA.
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