US 12,018,061 B2
Chimeric endocytic receptors and method of use thereof
Steven Lingfeng Liu, Seattle, WA (US); and Wenting Zhong, Wuping (CN)
Assigned to ST PHI THERAPEUTICS CO., LTD., Zhejiang (CN)
Filed by ST PHI THERAPEUTICS CO., LTD., Zhejiang (CN)
Filed on Mar. 9, 2020, as Appl. No. 16/813,417.
Claims priority of provisional application 62/919,382, filed on Mar. 8, 2019.
Prior Publication US 2020/0283495 A1, Sep. 10, 2020
Int. Cl. C07K 14/705 (2006.01); A61K 35/15 (2015.01); A61K 35/17 (2015.01); C07K 14/735 (2006.01); C07K 19/00 (2006.01); C12N 5/0783 (2010.01); C12N 5/0786 (2010.01); C12N 15/86 (2006.01)
CPC C07K 14/705 (2013.01) [A61K 35/15 (2013.01); A61K 35/17 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70532 (2013.01); C07K 14/70535 (2013.01); C07K 14/70578 (2013.01); C07K 19/00 (2013.01); C12N 5/0636 (2013.01); C12N 5/0645 (2013.01); C12N 15/86 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2319/01 (2013.01); C07K 2319/03 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15043 (2013.01)] 17 Claims
 
1. A chimeric endocytic antigen receptor (CER) complex comprising:
a) a homodimer of a chimeric polypeptide comprising an engagement element and a human Fc receptor transmembrane and cytoplasmic domain, and
b) two homodimers of Fc receptor gamma chain (FcR-γ),
wherein each chimeric polypeptide is associated with one of the homodimers of FcR-γ at the human Fc receptor transmembrane and cytoplasmic domain of the chimeric polypeptide.