| CPC C07D 239/74 (2013.01) [A61K 45/06 (2013.01); C07D 239/84 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 471/04 (2013.01); C07D 473/32 (2013.01); C07D 487/04 (2013.01)] | 15 Claims |
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1. A compound of Formula (II):
 or a pharmaceutically acceptable salt thereof, wherein:
 is selected from the group consisting of phenyl, piperidine, and pyrrolidine, each of which is substituted with E;
 is selected from the group consisting of
 wherein
 b is a point of attachment for and
 d is a point of attachment for  is selected from the group consisting of phenyl and pyridine;
X3 is C—R3;
X4 is C—R4;
X5 is C—R5;
R1, R3, R4, R5, and R6 are each independently selected from the group consisting of hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, and optionally substituted carbamimidoyl;
Q and Z are each independently selected at each occurrence from hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, and E;
E is selected from the group consisting of
 m is 0, 1, 2, 3, or 4; and
n is 0, 1, 2, 3, 4, or 5.
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