CPC A61K 9/006 (2013.01) [A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2031 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 31/4152 (2013.01)] | 20 Claims |
1. A sublingual pharmaceutical composition comprising edaravone or a salt thereof as a sole active ingredient, a filler, a binder and a disintegrant;
wherein the filler comprises mannitol but not comprises lactose;
wherein the binder comprises hydroxypropyl methylcellulose but does not comprises copovidone; and
wherein the disintegrant comprises at least one agent selected from the group consisting of croscarmellose sodium and crospovidone.
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10. A method of treating cerebrovascular disease or amyotrophic lateral sclerosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the sublingual pharmaceutical composition according to claim 1.
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