| CPC C07K 16/40 (2013.01) [C12N 15/52 (2013.01); G01N 33/574 (2013.01)] | 8 Claims |
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1. An antibody or fragment thereof specifically binding to an epitope consisting of a sequence of SEQ ID NO: 101, SEQ ID NO: 106, or SEQ ID NO: 111 in the lysyl-tRNA synthetase (KRS) N-terminus, wherein the antibody or fragment thereof specifically binds to an extracellularly exposed lysyl-tRNA synthetase (KRS) N-terminal region, wherein the antibody or fragment thereof comprises a heavy chain variable region and a light chain variable region which are selected from the group consisting of:
a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 1, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 3, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 5, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 7, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 9, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 11;
a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 13, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 15, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 17, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 19, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 21, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 23;
a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 25, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 27, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 29, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 31, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 33, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 35; and
a heavy chain variable region comprising heavy chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 37, heavy chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 39, and heavy chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 41, and a light chain variable region comprising light chain complementary determining region 1 containing the amino acid sequence defined by SEQ ID NO: 43, light chain complementary determining region 2 containing the amino acid sequence defined by SEQ ID NO: 45, and light chain complementary determining region 3 containing the amino acid sequence defined by SEQ ID NO: 47.
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