US 12,340,914 B2
Methods and systems for the production of isotopes
Dominic Maertens, Westerlo (BE); and Thomas Cardinaels, Mol (BE)
Assigned to SCK.CEN, Brussels (BE)
Appl. No. 17/765,656
Filed by SCK.CEN, Brussels (BE)
PCT Filed Aug. 16, 2020, PCT No. PCT/EP2020/072942
§ 371(c)(1), (2) Date Mar. 31, 2022,
PCT Pub. No. WO2021/063585, PCT Pub. Date Apr. 8, 2021.
Claims priority of application No. 19201581 (EP), filed on Oct. 4, 2019.
Prior Publication US 2022/0415533 A1, Dec. 29, 2022
Int. Cl. G21G 1/00 (2006.01); G21G 1/10 (2006.01)
CPC G21G 1/001 (2013.01) [G21G 1/10 (2013.01); G21G 2001/0089 (2013.01); G21G 2001/0094 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method for producing Pb-212 and Ac-225 isotopes, the method comprising:
irradiating a Ra-226 containing target with charged particles and producing an irradiated target comprising remaining Ra-226 and at least Ac-225 and Ac-224;
after the irradiating, waiting a first period of time during which the Ac-224 decays into Ra-224;
after the first period of time, applying a first extraction chromatography to the irradiated target and producing an actinium fraction containing the Ac-225 and a first radium fraction comprising the remaining Ra-226 and the Ra-224;
after the applying a first extraction chromatography, waiting a second period of time during which the Ra-224 in the first radium fraction decays into Pb-212;
after the second period of time, applying a second extraction chromatography to the first radium fraction and producing a first lead fraction comprising the Pb-212 and a second radium fraction comprising remaining Ra-226 and Ra-224, wherein the second extraction chromatography uses a resin having an 18-crown-6 ether or an equivalent of an 18-crown-6 ether, as extractant in HNO3 and/or HCl.