	US 12,338,434 B1
	Methods and materials for discovery of functional ligands to molecular complexes
George W. Jackson, Pearland, TX (US)
Assigned to BASE PAIR BIOTECHNOLOGIES, INC., Pearland, TX (US)
Filed by Base Pair Biotechnologies, Inc., Pearland, TX (US)
Filed on Jul. 13, 2020, as Appl. No. 16/927,346.
Application 16/927,346 is a continuation of application No. 16/369,716, filed on Mar. 29, 2019, abandoned.
Application 16/927,346 is a continuation of application No. 15/920,343, filed on Mar. 13, 2018, abandoned.
Claims priority of provisional application 62/470,600, filed on Mar. 13, 2017.
Int. Cl. C12N 15/10 (2006.01)

CPC C12N 15/1048 (2013.01)

10 Claims

1. A method for selecting functional ligands comprising:

providing a library of biomolecules;

contacting said library with a target, said target comprising a target ionic species comprising arsenic (III) ion complexed with a coordination compound, said coordination compound selected from the group consisting of 4-(mercaptomethyl)benzoic acid, 1,4-benzenedimethanethiol, meso-2,3-dimercaptosuccinic acid, 2,3-dimercapto-1-propanesulfonic acid, and 2,3-dimercapto-1-propanol;

sequestering members of said library which bind to said target, wherein said members bind via non-Watson-Crick and non-covalent binding;

determining the composition or sequence of said members which bind to said target.