US 12,338,426 B2
Cell stimulation apparatus, and ultrasonic and electrical stimulation apparatus
Hong Soo Choi, Daegu (KR); Eun Jung Shin, Daegu (KR); Hong Goo Yeo, Daejeon (KR); and Eun Hee Kim, Goyang-si (KR)
Assigned to DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY, Daegu (KR)
Appl. No. 17/284,108
Filed by DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY, Daegu (KR)
PCT Filed Oct. 7, 2019, PCT No. PCT/KR2019/013104
§ 371(c)(1), (2) Date Apr. 9, 2021,
PCT Pub. No. WO2020/116765, PCT Pub. Date Jun. 11, 2020.
Claims priority of application No. 10-2018-0153712 (KR), filed on Dec. 3, 2018.
Prior Publication US 2021/0348108 A1, Nov. 11, 2021
Int. Cl. C12M 1/42 (2006.01); C12M 1/34 (2006.01)
CPC C12M 35/02 (2013.01) [C12M 35/04 (2013.01); C12M 41/46 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A cell stimulation apparatus comprising:
an electrode unit in which an electrode element is installed and exposed as a portion of a top surface of the electrode unit, and configured to transmit electric stimulation;
a piezoelectric micromachined ultrasonic transducer (pMUT) element disposed above the electrode unit to be spaced apart from the electrode unit, and configured to generate an ultrasonic wave through a voltage applied thereto; and
a well element installed between the electrode unit and the pMUT element and forming a cell chamber together with the electrode unit and the pMUT element,
wherein the cell chamber is a closed space enclosed by the well element, the electrode unit, and the pMUT element, and
wherein a bio-sample is disposed directly on and directly contacts the electrode element, and receives the electric stimulation from the electrode element, and
wherein the ultrasonic wave generated by the pMUT element is transmitted to the bio-sample so as to provide ultrasound stimulation to the bio-sample located in the cell chamber.