US 12,338,300 B2
Polymer particles with a gradient composition and methods of production thereof
Darryl W. Brousmiche, Grafton, MA (US); Kevin Daniel Wyndham, Worcester, MA (US); Mingcheng Xu, Lexington, MA (US); and Michael F. Morris, Ashland, MA (US)
Assigned to Waters Technologies Corporation, Milford, MA (US)
Filed by Waters Technologies Corporation, Milford, MA (US)
Filed on May 13, 2024, as Appl. No. 18/662,095.
Application 18/662,095 is a continuation of application No. 16/287,364, filed on Feb. 27, 2019, granted, now 11,999,808.
Claims priority of provisional application 62/635,699, filed on Feb. 27, 2018.
Prior Publication US 2024/0301097 A1, Sep. 12, 2024
Int. Cl. C08F 212/08 (2006.01); C08F 2/04 (2006.01); C08F 2/06 (2006.01); C08F 220/56 (2006.01); C08K 5/00 (2006.01); C08K 5/14 (2006.01); C08K 5/23 (2006.01); C08L 39/06 (2006.01); C08F 220/28 (2006.01)
CPC C08F 2/04 (2013.01) [C08F 2/06 (2013.01); C08F 212/08 (2013.01); C08F 220/56 (2013.01); C08K 5/005 (2013.01); C08K 5/14 (2013.01); C08K 5/23 (2013.01); C08L 39/06 (2013.01); C08F 220/281 (2020.02); C08L 2205/24 (2013.01); C08L 2207/53 (2013.01)] 6 Claims
 
1. A non-porous polymer particle comprising a core having a center, a first layer, a second layer, and a particle surface, wherein:
the core comprises polystyrene, and wherein the core has a diameter greater than 0.1 micron;
the first layer extends radially from the core to an outer diameter, the first layer comprising a first polymer comprising units derived from styrene and units derived from divinylbenzene (DVB), wherein said first polymer is crosslinked with said units derived from DVB, wherein the first layer comprises a gradient of said units derived from DVB, and wherein an extent of crosslinking increases with radius;
the second layer extends radially from the outer diameter of the first layer to the particle surface, the second layer comprising a second polymer comprising units derived from glycidyl methacrylate (GMA) and units derived from ethylene glycol dimethacrylate (EDMA), wherein said second layer comprises a gradient of said units derived from GMA and said units derived from EDMA, and wherein a ratio of concentration of said units derived from GMA and said units derived from EDMA in the second layer to units derived from styrene and units derived from DVB in the first layer increases with radius, such that the particle surface consists essentially of polymerized GMA/EDMA.