US 12,338,251 B2
Substituted macrocycles useful as kinase inhibitors
Dawei Zhang, Thousand Oaks, CA (US)
Assigned to TELIGENE US LLC, Thousand Oaks, CA (US)
Filed by TELIGENE LTD, Suzhoou (CN)
Filed on Jan. 17, 2022, as Appl. No. 17/577,291.
Application 17/577,291 is a continuation of application No. PCT/CN2020/090070, filed on May 13, 2020.
Claims priority of provisional application 62/920,732, filed on May 14, 2019.
Prior Publication US 2022/0135592 A1, May 5, 2022
Int. Cl. C07D 498/18 (2006.01); A61P 35/00 (2006.01)
CPC C07D 498/18 (2013.01) [A61P 35/00 (2018.01)] 20 Claims
 
1. A compound according to Formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, solvate, or enantiomer thereof, wherein
R1 is C1-6 alkyl, or C1-6 alkoxy, provided that R1 is not tert-butoxyl.