US 12,338,236 B2
Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders
Ramakrishna Nirogi, Hyderabad (IN); Anil Karbhari Shinde, Hyderabad (IN); Abdul Rasheed Mohammed, Hyderabad (IN); Kumar Bojja, Hyderabad (IN); Rajesh Kumar Badange, Hyderabad (IN); Ramkumar Subramanian, Hyderabad (IN); Pradeep Jayarajan, Hyderabad (IN); Vijay Benade, Hyderabad (IN); and Venkateswarlu Jasti, Hyderabad (IN)
Assigned to SUVEN LIFE SCIENCES LIMITED, Hyderabad-Telangana (IN)
Appl. No. 18/832,280
Filed by SUVEN LIFE SCIENCES LIMITED, Hyderabad-Telangana (IN)
PCT Filed Jan. 27, 2023, PCT No. PCT/IB2023/050711
§ 371(c)(1), (2) Date Jul. 23, 2024,
PCT Pub. No. WO2023/144764, PCT Pub. Date Aug. 3, 2023.
Claims priority of application No. 202241004969 (IN), filed on Jan. 29, 2022.
Prior Publication US 2025/0101014 A1, Mar. 27, 2025
Int. Cl. C07D 417/14 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); C07D 413/14 (2006.01)
CPC C07D 417/14 (2013.01) [A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); C07D 413/14 (2013.01)] 5 Claims
 
1. A compound of formula (I),

OG Complex Work Unit Chemistry
or an isotopic form, a stereoisomer, or a pharmaceutically acceptable salt thereof,
wherein,
A is O or S;
R is N or CH;
Y is selected from —CH2—, —O—, NH, or —N(C1-4 alkyl)-;
n is an integer from 0 to 2;
R1 is selected from:

OG Complex Work Unit Chemistry
wherein, R2a, R2b, R2c, R2d and R2e are each independently selected from:

OG Complex Work Unit Chemistry
“custom character” represents the point of attachment;
R3 at each occurrence is independently selected from hydrogen, —(C1-4)alkyl, or —(C3-6) cycloalkyl; and
R4 is selected from hydrogen, halogen, —(C1-4)alkyl, —(C3-6) cycloalkyl or hydroxy-(C1-4)alkyl.