US 12,337,180 B2
Apparatus for brain stimulation
Sara Renata Francesca Marceglia, La Spezia (IT); Alberto Priori, Virgilio (IT); and Mattia Arlotti, Monza Brianza (IT)
Assigned to Newronika S.p.A., Milan (IT)
Filed by Newronika S.P.A., Milan (IT)
Filed on Mar. 28, 2022, as Appl. No. 17/706,378.
Application 17/706,378 is a continuation of application No. 16/706,552, filed on Dec. 6, 2019, granted, now 11,318,309.
Claims priority of provisional application 62/779,216, filed on Dec. 13, 2018.
Prior Publication US 2022/0323762 A1, Oct. 13, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36082 (2013.01) [A61N 1/0534 (2013.01); A61N 1/36135 (2013.01); A61N 1/36171 (2013.01); A61N 1/36175 (2013.01); A61N 1/36178 (2013.01)] 13 Claims
OG exemplary drawing
 
1. An apparatus comprising:
an implantable probe comprising an electrode configured for brain implantation; and
a stimulation device in communication with the implantable probe, wherein the stimulation device comprises:
an acquisition module in electrical communication with the implantable probe to acquire a neural activity signal from the electrode, and configured to be responsive to an acquisition processor to:
detect a decrease of a first power of the acquired neural activity signal in a first frequency band with respect to a first baseline value for a first predetermined duration followed by an increase in the first power with respect to the first baseline value for a second predetermined duration, and
modify an electrical stimulation parameter if the decrease followed by the increase of the first power of the acquired neural activity signal is detected; and
a stimulation module having a voltage source or current source configured to generate and transmit to the electrode a stimulation signal in accordance with the modified electrical stimulation parameter.