US 12,337,151 B2
Stopper
Bernd Kuehn, Frankfurt am Main (DE)
Assigned to Sanofi, Paris (FR)
Appl. No. 16/968,735
Filed by SANOFI, Paris (FR)
PCT Filed Feb. 8, 2019, PCT No. PCT/EP2019/053195
§ 371(c)(1), (2) Date Aug. 10, 2020,
PCT Pub. No. WO2019/155018, PCT Pub. Date Aug. 15, 2019.
Claims priority of application No. 18305141 (EP), filed on Feb. 12, 2018.
Prior Publication US 2021/0001053 A1, Jan. 7, 2021
Int. Cl. A61M 5/315 (2006.01); A61M 5/20 (2006.01); A61M 5/24 (2006.01); A61M 5/31 (2006.01)
CPC A61M 5/31563 (2013.01) [A61M 5/2455 (2013.01); A61M 5/31513 (2013.01); A61M 5/20 (2013.01); A61M 2005/2492 (2013.01); A61M 2005/3123 (2013.01); A61M 2205/3327 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A stopper for use in a cartridge or a syringe of a medical device, the stopper configured to be disposed within a container closure system, the stopper comprising:
a shell comprising a closed end and an open end with sidewalls extending between the closed end and the open end along a longitudinal axis of the shell, the open end defining a cavity and the sidewalls defining an exterior surface sized and shaped to fit inside the container closure system; and
an insert configured to be inserted into the cavity, the insert comprising a distal end and a proximal end and being sized and shaped to receive a force from a plunger rod and distribute the force to the shell to advance the shell into the container closure system,
wherein the closed end of the shell in the cavity defines a convex surface that is curved into the cavity and configured to be contacted and deflected by the insert upon insertion of the insert into the cavity,
wherein the closed end of the shell is made of an elastic and/or plastic deformable material,
wherein the cavity comprises an interior step element, and wherein the insert comprises a corresponding step element configured to abut the interior step element and distribute at least a portion of the force from the plunger rod to the interior step element, and
wherein the insert is constructed of a plurality of segments, whereby the segments decrease in size toward the distal end of the insert.