US 12,337,129 B2
Long-acting antibacterial anti-stenosis functional urethral stent and preparation method thereof
Gang Li, Suzhou (CN); Lu Li, Suzhou (CN); Feng Li, Suzhou (CN); and Lirong Duan, Suzhou (CN)
Assigned to NANTONG TEXTILE & SILK INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, Nantong (CN); and SOOCHOW UNIVERSITY, Suzhou (CN)
Appl. No. 18/577,719
Filed by NANTONG TEXTILE & SILK INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, Nantong (CN); and SOOCHOW UNIVERSITY, Suzhou (CN)
PCT Filed Mar. 22, 2022, PCT No. PCT/CN2022/082332
§ 371(c)(1), (2) Date Jan. 9, 2024,
PCT Pub. No. WO2023/284329, PCT Pub. Date Jan. 19, 2023.
Claims priority of application No. 202110800298.4 (CN), filed on Jul. 15, 2021.
Prior Publication US 2024/0261548 A1, Aug. 8, 2024
Int. Cl. A61L 31/16 (2006.01); A61L 31/02 (2006.01); A61L 31/10 (2006.01); A61L 31/14 (2006.01); A61M 27/00 (2006.01); D03D 3/02 (2006.01)
CPC A61M 27/008 (2013.01) [A61L 31/022 (2013.01); A61L 31/10 (2013.01); A61L 31/14 (2013.01); A61L 31/16 (2013.01); D03D 3/02 (2013.01); A61L 2300/404 (2013.01); A61L 2300/416 (2013.01); A61L 2400/18 (2013.01); A61M 2207/00 (2013.01); A61M 2210/1089 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A long-acting antibacterial anti-stenosis functional urethral stent, wherein the urethral stent is a tubular structure consisting of three layers: inner, middle and outer layers;
wherein the middle layer is a fabric tube; wherein the outer layer is a silk fibroin film carrying anti-stenosis drugs; wherein the inner layer is an antibacterial antifouling coating, consisting of chitosan-nanosilica arrays, villi, microvilli and antibacterial drugs;
wherein the chitosan-nanosilica array arranged on an inner surface of the fabric tube, is a nanosilica array carrying chitosan molecules; one end of the villus is fixed on a surface of the chitosan-nanosilica array while the other end is a free end, and a material of the villus is a polymer containing polyhydroxy functional group, which is bonded with the chitosan in the chitosan-nanosilica array through covalent bonds, and a number of hydroxyl of the polymer containing polyhydroxy functional group is greater than or equal to 2; one end of the microvillus is fixed to the villus while the other end is a free end, and a material of the microvillus is a polymer with antibacterial adhesion function, which is bonded with the villus through covalent bonds; wherein the antibacterial drug is distributed in the whole inner layer,
wherein the fabric tube consists of yarns; wherein the yarn is one or more selected from the group consisting of silk, a polylactide filament, a polydiaxone filament, a polyglycolide acid filament, a poly (lactic-co-glycolic acid) filament and a developing wire;
wherein the fabric tube has a radial compression modulus of 0.03-5.72 MPa, an elastic recovery ratio of 74.53-93.63%, a circumferential expansion breaking strength of 0.03-10.62 MPa, and a yarn coverage rate of 66.67-83.15%;
wherein the anti-stenosis drug is rapamycin and/or curcumin;
wherein the polymer containing polyhydroxy functional group is one or more selected from the group consisting of polyether, polyvinyl alcohol, polyethylene glycol, polyhydroxyethyl methacrylate and acrylic acid-hydroxypropyl acrylate copolymer;
wherein the polymer with antibacterial adhesion function is one or more selected from the group consisting of cationic polymer, anionic polymer, nonionic polymer and zwitterionic hydrophilic polymer;
wherein the antibacterial drug is one or more selected from the group consisting of antibacterial peptide, triclosan, heparin, clarithromycin, berberine, sparfloxacin, amikacin and ketolovic acid.