	US 12,337,075 B2
	Extracellular matrix-based bioadhesive
Hyeon Ji Kim, Changwon-si (KR); Je Hwan Jang, Seoul (KR); Won Il Han, Pohang-si (KR); Joon Young Kim, Seoul (KR); Jin Ah Jang, Pohang-si (KR); and Dong Woo Cho, Seoul (KR)
Assigned to POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION, Pohang-si (KR); and KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP, Seoul (KR)
Filed by POSTECH Research and Business Development Foundation, Pohang-si (KR); and Konkuk University Industrial Cooperation Corp, Seoul (KR)
Filed on Sep. 29, 2022, as Appl. No. 17/936,385.
Claims priority of application No. 10-2021-0133757 (KR), filed on Oct. 8, 2021.
Prior Publication US 2023/0111780 A1, Apr. 13, 2023
Int. Cl. A61L 24/00 (2006.01); A61L 24/10 (2006.01)

CPC A61L 24/0031 (2013.01) [A61L 24/104 (2013.01)]

4 Claims

1. An extracellular matrix-based bioadhesive as an adhesive in the form of a composition including a gelatinized extracellular matrix-containing hydrogel and a gelatin curing agent,

wherein the gelatinized extracellular matrix-containing hydrogel is obtained by heat-treating an extracellular matrix-containing hydrogel at a temperature of 50 to 60° C. and a pH of 6 to 8.5,

wherein the extracellular matrix is a decellularized extracellular matrix,

wherein the gelatinized extracellular matrix-containing hydrogel is obtained by thermal denaturation of collagen, which is a component of an extracellular matrix.