	US 12,337,005 B2
	Methods of treating thrombosis
Anil Chauhan, Iowa City, IA (US); and Manasa K. Nayak, Iowa City, IA (US)
Assigned to UNIVERSITY OF IOWA RESEARCH FOUNDATION, Iowa City, IA (US)
Filed by UNIVERSITY OF IOWA RESEARCH FOUNDATION, Iowa City, IA (US)
Filed on May 26, 2021, as Appl. No. 17/331,366.
Claims priority of provisional application 63/030,084, filed on May 26, 2020.
Prior Publication US 2021/0369742 A1, Dec. 2, 2021
Int. Cl. A61K 31/63 (2006.01); A61K 31/5025 (2006.01); A61K 45/06 (2006.01); A61P 7/02 (2006.01)

CPC A61K 31/63 (2013.01) [A61K 31/5025 (2013.01); A61K 45/06 (2013.01); A61P 7/02 (2018.01)]

5 Claims

1. A method of inhibiting thrombosis without altering hemostasis by administering a composition comprising an inhibitor of dimeric pyruvate kinase M2 (PKM2) or an activator/stabilizer of tetramer PKM2 in a patient in need thereof,

wherein the dimeric PKM2 inhibitor or activator/stabilizer of tetramer PKM2 is ML265; and

wherein the administration of the composition does not alter hemostasis in the patient.