US 12,336,842 B2
Anesthetizing monitoring system, unit and method therefore
David Robert Hampton, Woodinville, WA (US)
Assigned to Senzime AB, Uppsala (SE)
Appl. No. 16/981,320
Filed by Senzime AB, Uppsala (SE)
PCT Filed Mar. 11, 2019, PCT No. PCT/SE2019/050220
§ 371(c)(1), (2) Date Sep. 16, 2020,
PCT Pub. No. WO2019/177526, PCT Pub. Date Sep. 19, 2019.
Claims priority of application No. 1850294-8 (SE), filed on Mar. 16, 2018.
Prior Publication US 2021/0007661 A1, Jan. 14, 2021
Int. Cl. A61B 5/00 (2006.01); A61B 5/11 (2006.01); A61B 5/389 (2021.01)
CPC A61B 5/4821 (2013.01) [A61B 5/0017 (2013.01); A61B 5/1106 (2013.01); A61B 5/389 (2021.01); A61B 5/7203 (2013.01); A61B 5/742 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method performed by an anesthetizing monitoring unit configured to generate an improved evoked electromyography response signal (ΣResponse), the method comprising:
generating a single stimuli signal (SStimuli) using the anesthetizing monitoring unit, wherein the single stimuli signal (SStimuli) comprises a single pulse and is configured to stimulate a motor nerve of a patient,
outputting the generated single stimuli signal (SStimuli) to stimulating electrodes on the patient using an output port of the anesthetizing monitoring unit,
receiving a single evoked electromyography, EMG, response signal (SResponse) from receiving electrodes on the patient at an input port of the anesthetizing monitoring unit, having a duration (TResponse), in response to the outputted stimuli signal (SStimuli),
estimating a periodic noise waveform (SPeriodic), having the duration (TResponse), based on a noise signal (SNoise) by splitting the noise signal (SNoise) into temporal segments, wherein:
the noise signal (SNoise) is caused by an electric power grid having a frequency;
the temporal segments each have a periodic duration (TPeriodic) matching the frequency of the electric power grid; and
the temporal segments of the noise signal (SNoise) are detected during a time interval (TNoise) not overlapping with a stimuli signal interval (TStimulus) of the single stimuli signal (SStimuli) and not overlapping with the duration of the response signal (TResponse),
generating the improved response signal (ΣResponse) by subtracting the noise waveform from the response signal (SResponse) to reduce noise in the response signal (SResponse) caused by the electric power grid,
storing the improved response signal (ΣResponse) in a memory in the anesthetizing monitoring unit, and
presenting the improved response signal (ΣResponse) on a display in the anesthetizing monitoring unit.