US 12,336,839 B2
Quantitative dynamic MRI (QDMRI) analysis and virtual growing child (VGC) systems and methods for treating respiratory anomalies
Jayaram K. Udupa, Philadelphia, PA (US); Yubing Tong, Springfield, PA (US); Drew A. Torigian, Philadelphia, PA (US); You Hao, Philadelphia, PA (US); Changjian Sun, Philadelphia, PA (US); Joseph M. McDonough, Ambler, PA (US); and Patrick J. Cahill, Merion Station, PA (US)
Assigned to The Children's Hospital of Philadelphia, Philadelphia, PA (US)
Appl. No. 17/794,032
Filed by The Children's Hospital of Philadelphia, Philadelphia, PA (US); and The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
PCT Filed Feb. 10, 2021, PCT No. PCT/US2021/017356
§ 371(c)(1), (2) Date Jul. 20, 2022,
PCT Pub. No. WO2021/163116, PCT Pub. Date Aug. 19, 2021.
Claims priority of provisional application 62/972,242, filed on Feb. 10, 2020.
Prior Publication US 2023/0050512 A1, Feb. 16, 2023
Int. Cl. G06K 9/00 (2022.01); A61B 5/00 (2006.01); G06T 7/00 (2017.01); G06T 7/11 (2017.01); G06T 7/174 (2017.01); G06T 7/20 (2017.01); G06T 7/62 (2017.01); G06T 17/00 (2006.01); G06V 10/22 (2022.01)
CPC A61B 5/4538 (2013.01) [A61B 5/4842 (2013.01); G06T 7/0014 (2013.01); G06T 7/11 (2017.01); G06T 7/174 (2017.01); G06T 7/20 (2013.01); G06T 7/62 (2017.01); G06T 17/00 (2013.01); G06V 10/22 (2022.01); G06T 2207/10088 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/30048 (2013.01); G06T 2207/30061 (2013.01); G06T 2207/30196 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A method of analyzing thoracic insufficiency syndrome (TIS) in a subject, the method comprising the steps of:
performing, by a processor, quantitative dynamic magnetic resonance imaging (QdMRI) analysis by:
performing, by a processor, four-dimensional (4D) image construction of a TIS subject's thoracic cavity, the 4D image includes a sequence of two dimensional (2D) images of the TIS subject's thoracic cavity over a respiratory cycle of the TIS subject,
segmenting, by the processor, a region of interest (ROI) within the 4D image,
determining, by the processor, TIS measurements within the ROI,
comparing, by the processor, the TIS measurements to normal measurements determined from ROIs in 4D images of the thoracic cavities of normal subjects that are not afflicted by TIS, and
outputting, by the processor, quantitative markers indicating deviation of the thoracic cavity of the TIS subject relative to the thoracic cavities of the normal subjects.