US 12,336,820 B2
Methods of preparing/optimizing perfume compositions
Thomas Briere, Paris (FR); Julia Brooks, Ashford (GB); Ioannis Kontaris, Ashford (GB); Kristopher George Magee, Bristol (GB); and Christopher Pley-Dell-Pearce, Bristol (GB)
Assigned to GIVAUDAN SA, Vernier (CH)
Appl. No. 17/619,646
Filed by GIVAUDAN SA, Vernier (CH)
PCT Filed May 1, 2020, PCT No. PCT/EP2020/062178
§ 371(c)(1), (2) Date Dec. 16, 2021,
PCT Pub. No. WO2020/165463, PCT Pub. Date Aug. 20, 2020.
Claims priority of application No. 1909221 (GB), filed on Jun. 27, 2019.
Prior Publication US 2022/0334094 A1, Oct. 20, 2022
Int. Cl. A61B 5/16 (2006.01); C11B 9/00 (2006.01); A61M 21/00 (2006.01)
CPC A61B 5/165 (2013.01) [C11B 9/00 (2013.01); C11B 9/0007 (2013.01); C11B 9/0061 (2013.01); A61M 2021/0016 (2013.01)] 2 Claims
 
1. A method of preparing or optimizing a perfume composition which enhances the well-being of a human subject, the method comprising:
a) having one or more human subject(s) assess their well-being in the absence of a test perfume composition by scoring a plurality of well-being attributes;
i. wherein the well-being attributes include “not anxious”, “not sad”, “not restless”, “not frustrated”, “not stressed”, “happy”, “optimistic”, “excited”, “satisfied”, “motivated”, “invigorated”, “interested”, “not bored”, “not fatigued”, “mentally alert”, “calm”, “relaxed”, and “patient”; and
ii. wherein each well-being attribute has a weight;
b) calculating a base well-being score in the absence of the test perfume composition by multiplying the score of each well-being attribute by the corresponding weight to form a product and summing these products over all well-being attributes;
c) repeating a) and b) in the presence of the test perfume composition in order to determine a test well-being score with the test perfume composition;
d) determining the impact of the test perfume composition on the well-being by subtracting the base well-being score from the test well-being score with the test perfume composition;
e) selecting perfume compositions with a positive impact on the well-being based on the determined impact of the test perfume composition;
f) comparing perfume ingredients present in the selected perfume compositions having a positive impact on the well-being;
g) identifying odour attributes common to the selected perfume compositions based on the compared perfume ingredients; and
h) creating a new perfume composition with an increased proportion of perfume ingredients with the odour attributes identified in g),
wherein the weights of the well-being attributes are as follows:
 
 
 
well-being attribute weight
 
 
 
“not anxious” 10.65% 
 
“not sad” 10.32% 
 
“not restless” 9.84%
 
“not frustrated” 9.65%
 
“not stressed” 7.54%
 
“happy” 4.70%
 
“optimistic” 4.61%
 
“excited” 4.13%
 
“satisfied” 3.91%
 
“motivated” 3.34%
 
“invigorated” 3.31%
 
“interested” 6.12%
 
“not bored” 5.88%
 
“not fatigued” 4.59%
 
“mentally alert” 4.41%
 
“calm” 2.66%
 
“relaxed” 2.24%
 
“patient”  2.10%.