US 12,336,816 B2
Method for improved sensor sensitivity of a microneedle-based continuous analyte monitoring system
Alan Steven Campbell, La Mesa, CA (US); Robert McKinlay, San Marcos, CA (US); and Shuai Xu, San Diego, CA (US)
Assigned to Biolinq Incorporated, San Diego, CA (US)
Filed by Biolinq Incorporated, San Diego, CA (US)
Filed on Feb. 2, 2024, as Appl. No. 18/431,808.
Claims priority of provisional application 63/613,566, filed on Dec. 21, 2023.
Claims priority of provisional application 63/443,010, filed on Feb. 2, 2023.
Claims priority of provisional application 63/443,024, filed on Feb. 2, 2023.
Prior Publication US 2024/0315614 A1, Sep. 26, 2024
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/14546 (2013.01) [A61B 5/685 (2013.01); A61B 2562/125 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A device for use in sensing an analyte, comprising:
a microneedle;
an electrode material on the microneedle;
a biorecognition layer on the electrode material, the biorecognition layer comprising a polymer, a biorecognition element configured to react with the analyte, and an interferent blocking agent that fills voids within the polymer, at least a portion of the interferent blocking agent being in contact with the electrode material; and
a diffusion-limiting layer on the biorecognition layer,
wherein the interferent blocking agent comprises polymerized phenol and the polymerized phenol is present within the biorecognition layer at a concentration of between about 0.1 mg/ml or 0.01% w/v and about 10 mg/ml or 1% w/v.