| CPC A61B 5/14532 (2013.01) [A61B 5/14865 (2013.01); A61B 5/1495 (2013.01); A61B 2560/0223 (2013.01); Y10T 436/144444 (2015.01)] | 20 Claims |

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1. A method of determining a non-attenuated sensitivity of a glucose sensor positioned in fluid contact with interstitial fluid, comprising:
generating, by the glucose sensor, electrical signals indicative of a glucose level in the interstitial fluid;
obtaining, by a data processing unit operatively coupled with the glucose sensor, a plurality of data points from the signals generated by the glucose sensor, wherein the data processing unit comprises one or more processors, a transceiver to transmit data to a receiving unit, and a memory storing instructions which when executed by the one or more processors enable the data processing unit to perform specified operations;
pairing, by the data processing unit, the plurality of data points with reference data from a reference data source to form a plurality of pairs;
forming, by the data processing unit, a plurality of groups each including one or more of the plurality of pairs;
determining, by the data processing unit, a representative sensitivity of the glucose sensor for each of the plurality of groups, wherein the representative sensitivity of a group is based on corresponding sensitivities of the one or more of the plurality of pairs included in the group;
selecting, by the data processing unit, one or more of the representative sensitivities based on the selected representative sensitivities satisfying one or more criteria;
determining, by the data processing unit, the non-attenuated sensitivity based on a weighted average of the selected representative sensitivities;
applying, by the data processing unit, the determined non-attenuated sensitivity to the plurality of data points obtained from the glucose sensor to estimate a glucose level; and
causing, by the data processing unit, output of an alarm to a user based on the estimated glucose level.
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