US 12,336,810 B2
Detection of a chemical species in the sweat of a subject
Philippe Riviere, Toulouse (FR); Christian Amatore, Paris (FR); Gilles Favre, Cugnaux (FR); Marc Labrunee, Toulouse (FR); and Frederic Daumas, Pinsaguel (FR)
Assigned to NOPTRACK, Castres (FR)
Appl. No. 17/778,258
Filed by NOPTRACK, Castres (FR)
PCT Filed Nov. 24, 2020, PCT No. PCT/EP2020/083210
§ 371(c)(1), (2) Date May 19, 2022,
PCT Pub. No. WO2021/105122, PCT Pub. Date Jun. 3, 2021.
Claims priority of application No. 1913400 (FR), filed on Nov. 28, 2019.
Prior Publication US 2023/0337945 A1, Oct. 26, 2023
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/1477 (2006.01); A61B 10/00 (2006.01); A61B 5/11 (2006.01)
CPC A61B 5/14517 (2013.01) [A61B 5/0004 (2013.01); A61B 5/02055 (2013.01); A61B 5/14546 (2013.01); A61B 5/1477 (2013.01); A61B 10/0064 (2013.01); A61B 5/1118 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A detection apparatus (1) for detecting at least one chemical species dissolved in the sweat of a human or animal subject, said at least one dissolved chemical species including nitric oxide NO, said apparatus comprising:
a collecting element (5) intended to be placed on an investigation zone of a subject's epidermis (2),
a detection device comprising at least one fluidic circuit (8, 9) coupled to the collecting element in order to conduct at least one flow of sweat originating from the investigation zone, and at least one electrochemical sensor (10) comprising electrodes disposed in the at least one fluidic circuit, in which said electrodes comprise at least one working electrode (20) and a counter-electrode (30), the at least one electrochemical sensor being configured to produce at least a signal that is representative of a concentration of nitric oxide NO in the flow of sweat by an electrical measurement between the at least one working electrode and the counter-electrode,
wherein said electrodes further comprise an upstream working electrode (20) and a downstream working electrode (23) spaced apart in the at least one fluidic circuit in a direction of flow (12) of the flow of sweat, and the at least one electrochemical sensor being configured to produce a signal that is representative of a flow velocity of the flow of sweat by measuring a delay (Δt) between a variation in current in the upstream working electrode and a variation in current in the downstream working electrode.