US 12,336,804 B2
System and method for diagnosing and treating biological rhythm disorders
Sanjiv M. Narayan, Palo Alto, CA (US); Miguel Rodrigo Bort, Valencia (ES); and Mahmood I. Alhusseini, Menlo Park, CA (US)
Assigned to PhysCade, Inc., Palo Alto, CA (US)
Filed by PhysCade, Inc., Palo Alto, CA (US)
Filed on Dec. 24, 2022, as Appl. No. 18/088,523.
Application 18/088,523 is a continuation of application No. 17/708,991, filed on Mar. 30, 2022, granted, now 11,564,591.
Claims priority of provisional application 63/283,901, filed on Nov. 29, 2021.
Prior Publication US 2023/0200676 A1, Jun. 29, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/277 (2021.01); A61B 5/00 (2006.01); A61B 5/06 (2006.01); A61B 5/287 (2021.01); G16H 50/70 (2018.01)
CPC A61B 5/068 (2013.01) [A61B 5/277 (2021.01); A61B 5/287 (2021.01); A61B 5/7267 (2013.01); A61B 5/742 (2013.01); G16H 50/70 (2018.01)] 21 Claims
OG exemplary drawing
 
1. A treatment system for providing therapy to treat a heart rhythm disorder, the treatment system comprising:
a control system; and
a heart treatment device comprising a catheter and a sensing array;
wherein:
the sensing array is arranged on the catheter and configured to be coupled to a human heart;
the sensing array is configured to generate data in dependence on measurement of a set of electrical signals of the human heart, wherein each electrical signal of the set of electrical signals is measured by a sensing element of the sensing array;
the heart treatment device is configured to transmit the generated data to the control system;
the control system is configured to recreate, in dependence on the data received from the heart treatment device, an action potential signal for each of the electrical signals;
the control system is configured to input the action potential signals into a guidance model to determine a guidance direction of a catheter of the heart treatment device towards a critical region, wherein the guidance model is a machine-learned model that is trained using a plurality of training samples, each training sample comprising reconstructed action potential signals of one or more other human hearts measured by another sensing array and the respective directions towards the critical region;
the control system is configured to generate instructions for the heart treatment device, wherein the instructions provide a guidance direction to the catheter such that the catheter is guided towards a critical region for receiving therapy; and
the heart treatment device is configured to receive the generated instructions, from the control system, such that the catheter is guided towards the critical region for receiving therapy.