US 12,336,786 B2
Photoacoustic imaging system, and laser energy correction method and prompting method therefor
Fang Yang, Shenzhen (CN); Xujin He, Shenzhen (CN); Lei Zhu, Shenzhen (CN); and Xiaoyun Chang, Shenzhen (CN)
Assigned to Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen (CN)
Filed by SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., Guangdong (CN)
Filed on Dec. 9, 2022, as Appl. No. 18/078,858.
Claims priority of application No. 202111498408.2 (CN), filed on Dec. 9, 2021.
Prior Publication US 2023/0181044 A1, Jun. 15, 2023
Int. Cl. A61B 5/00 (2006.01)
CPC A61B 5/0095 (2013.01) [A61B 5/7235 (2013.01); A61B 5/7425 (2013.01); A61B 2560/0223 (2013.01); A61B 2562/0204 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A laser energy correction method in a photoacoustic imaging system, comprising:
controlling a laser to transmit a first optical pulse to a target tissue;
receiving a first acoustic wave generated by the target tissue absorbing the first optical pulse to acquire a first photoacoustic signal, and receiving a third acoustic wave generated by a marker absorbing the first optical pulse to acquire a third photoacoustic signal;
controlling the laser to transmit a second optical pulse to the target tissue, the first optical pulse having a first wavelength and the second optical pulse having a second wavelength different from the first wavelength;
receiving a second acoustic wave generated by the target tissue absorbing the second optical pulse to acquire a second photoacoustic signal, and receiving a fourth acoustic wave generated by the marker absorbing the second optical pulse to acquire a fourth photoacoustic signal;
correcting a signal intensity of the first photoacoustic signal based on a signal intensity of the third photoacoustic signal together with a first absorption coefficient of the marker with respect to the first optical pulse, and correcting a signal intensity of the second photoacoustic signal based on the fourth photoacoustic signal together with a second absorption coefficient of the marker with respect to the second optical pulse; and
acquiring an oxygen saturation of the target tissue based on the corrected signal intensity of the first photoacoustic signal and the corrected signal intensity of the second photoacoustic signal,
wherein a material of the marker comprises a material with light-absorbing properties, and the first absorption coefficient of the marker with respect to the first optical pulse and the second absorption coefficient of the marker with respect to the second optical pulse are capable of being acquired based on an absorption spectrum in an imaging wavelength range of the marker.