US 12,336,770 B2
Endoscopic ultrasound electroporation
Samuel J. Asirvatham, Rochester, MN (US); and Barham K. Abu Dayyeh, Rochester, MN (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on May 2, 2023, as Appl. No. 18/142,385.
Application 18/142,385 is a continuation of application No. 16/644,785, granted, now 11,672,608, previously published as PCT/US2018/049682, filed on Sep. 6, 2018.
Claims priority of provisional application 62/554,859, filed on Sep. 6, 2017.
Prior Publication US 2023/0263578 A1, Aug. 24, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 34/20 (2016.01); A61B 1/015 (2006.01); A61B 8/00 (2006.01); A61B 8/08 (2006.01); A61B 8/12 (2006.01); A61B 18/00 (2006.01); A61B 18/06 (2006.01); A61B 18/18 (2006.01); A61N 1/32 (2006.01); A61N 5/06 (2006.01)
CPC A61B 34/20 (2016.02) [A61B 1/015 (2013.01); A61B 8/0841 (2013.01); A61B 8/12 (2013.01); A61B 8/445 (2013.01); A61B 18/00 (2013.01); A61B 18/06 (2013.01); A61B 18/18 (2013.01); A61N 1/327 (2013.01); A61N 5/062 (2013.01); A61B 2018/0022 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00982 (2013.01); A61B 2018/1807 (2013.01); A61B 2034/2063 (2016.02)] 16 Claims
OG exemplary drawing
 
14. An endoscopically-deliverable ultrasound-guided electroporation needle system, the electroporation needle system comprising:
an endoscope comprising an ultrasound head located at a distal end thereof, the endoscope defining a working channel with an outlet at the distal end of the endoscope;
a single elongate needle shaft defining a longitudinal axis and slidably disposable within the working channel of the endoscope;
a first aperture defined at a distal end portion of the needle shaft, the first aperture configured to aspirate a first fluid through a lumen defined by the elongate needle shaft;
a second aperture defined by the distal end portion of the needle shaft and arranged linearly with respect to the first aperture longitudinally along the needle shaft, the second aperture configured to inject a second fluid through the lumen; and
three electrodes arranged on the needle shaft proximal of the distal end portion of the needle shaft, wherein the three electrodes are longitudinally spaced apart from each other along the needle shaft and are configured to simultaneously generate two separate electrical fields in the second fluid,
wherein the needle shaft, including the portion of the needle shaft on which the three electrodes are arranged, is configured for insertion into a cystic structure such that the three electrodes are positioned within the cystic structure, and
wherein the distal end portion of the needle shaft is free of any electrodes.