US 12,336,727 B2
Devices, systems and methods to remove blood clots
Paul A. Spence, Louisville, KY (US)
Assigned to Ischemicure Ltd., Louisville, KY (US)
Filed by Ischemicure Ltd., Louisville, KY (US)
Filed on Jun. 11, 2024, as Appl. No. 18/740,004.
Application 18/740,004 is a continuation of application No. 18/475,929, filed on Sep. 27, 2023.
Application 18/475,929 is a continuation of application No. 17/379,566, filed on Jul. 19, 2021, granted, now 11,793,532, issued on Oct. 24, 2023.
Application 17/379,566 is a continuation of application No. 16/637,046, granted, now 11,065,017, issued on Jul. 20, 2021, previously published as PCT/US2019/015220, filed on Jan. 25, 2019.
Claims priority of provisional application 62/775,510, filed on Dec. 5, 2018.
Claims priority of provisional application 62/654,693, filed on Apr. 9, 2018.
Claims priority of provisional application 62/621,776, filed on Jan. 25, 2018.
Prior Publication US 2024/0366246 A1, Nov. 7, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 17/22 (2006.01); A61B 17/12 (2006.01); A61B 17/221 (2006.01); A61B 17/3203 (2006.01); A61F 2/01 (2006.01); A61F 2/844 (2013.01); A61F 2/958 (2013.01); A61M 1/00 (2006.01); A61B 6/00 (2006.01); A61B 6/50 (2024.01); A61B 17/00 (2006.01); A61M 25/10 (2013.01); A61M 39/00 (2006.01)
CPC A61B 17/221 (2013.01) [A61B 17/1204 (2013.01); A61B 17/12109 (2013.01); A61B 17/22 (2013.01); A61B 17/32037 (2013.01); A61F 2/013 (2013.01); A61F 2/844 (2013.01); A61F 2/958 (2013.01); A61M 1/75 (2021.05); A61M 1/79 (2021.05); A61M 1/85 (2021.05); A61M 1/87 (2021.05); A61B 6/481 (2013.01); A61B 6/501 (2013.01); A61B 6/504 (2013.01); A61B 2017/00323 (2013.01); A61B 2017/00867 (2013.01); A61B 17/12168 (2013.01); A61B 2017/22079 (2013.01); A61M 2025/1052 (2013.01); A61M 2039/0009 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A system for imaging a blood clot within a blood vessel, the system comprising:
an elongate body having a radially expandable distal seal configured to be introduced into the blood vessel and beyond the blood clot such that the distal seal is disposed distal to the blood clot, the distal seal defining an opening at a proximal portion thereof and being a membrane, the elongate body defining a lumen and at least one perforation located distal to a proximal end of the distal seal and proximal to a distal end of the distal seal, the distal seal being configured to expand by introduction of a fluid imaging agent through the at least one perforation while simultaneously expelling a portion of the fluid imaging agent through the opening to enable imaging of the blood clot; and
a fluid delivery apparatus configured to deliver the fluid imaging agent through the lumen and the at least one perforation in the elongate body into an area between the blood clot and the distal end of the distal seal to increase a pressure within the area to expand the distal seal to form a fluid pressure seal against an interior wall surface of the blood vessel distal to the blood clot, the imaging agent being viewable via an imaging modality when the imaging agent is disposed within the area such that at least a portion of the blood clot within the blood vessel can be identified.