US 12,014,835 B2
Methods for evaluating therapeutic benefit of combination therapies
Christian T. Meyer, Nashville, TN (US); Vito Quaranta, Nashville, TN (US); Leonard A. Harris, Nashville, TN (US); Buddhi Bishal Paudel, Nashville, TN (US); David J. Wooten, Nashville, TN (US); and Laurent Audoly, Brookline, MA (US)
Assigned to Vanderbilt University, Nashville, TN (US); and Duet BioSystems Inc., Nashville, TN (US)
Filed by Vanderbilt University, Nashville, TN (US); and DUET Biosystems, Inc., Nashville, TN (US)
Filed on Feb. 19, 2021, as Appl. No. 17/180,280.
Claims priority of provisional application 62/978,530, filed on Feb. 19, 2020.
Prior Publication US 2021/0358642 A1, Nov. 18, 2021
Int. Cl. G16H 70/20 (2018.01); G16C 20/30 (2019.01)
CPC G16H 70/20 (2018.01) [G16C 20/30 (2019.02)] 20 Claims
OG exemplary drawing
 
1. A method for evaluating the therapeutic benefit of a combination therapy comprising a first therapeutic agent and a second therapeutic agent to be used in combination to treat a medical disorder, the method comprising the steps of:
(a) determining, with an electronic processor, a difference in efficacy towards the medical disorder between (i) the combination and (ii) the most efficacious single therapeutic agent in the combination;
(b) determining, with the electronic processor, a difference in potency towards the medical disorder for the first therapeutic agent between when (i) the first therapeutic agent is used alone and (ii) the first therapeutic agent is used in combination with the second therapeutic agent;
(c) determining, with the electronic processor, a difference in potency towards the medical disorder for the second therapeutic agent between when (i) the second therapeutic agent is used alone and (ii) the second therapeutic agent is used in combination with the first therapeutic agent;
(d) selecting the combination, the first therapeutic agent, or the second therapeutic agent, to prescribe for a patient, based on the determining steps of (a), (b), and (c); and
optionally, administering the selected one of the combination, the first therapeutic agent, or the second therapeutic agent to the patient.