US 12,013,404 B2
Apparatus for measuring glycation of red blood cells and glycated hemoglobin level using physical and electrical characteristics of cells, and related methods
Ung Hyeon Ko, Seoul (KR); Seung Jin Kang, Seoul (KR); and Eun Young Park, Seoul (KR)
Assigned to ORANGE BIOMED LTD., CO., Seoul (KR)
Filed by ORANGE BIOMED LTD., CO., Seoul (KR)
Filed on Aug. 2, 2023, as Appl. No. 18/364,441.
Application 18/364,441 is a continuation of application No. 18/064,233, filed on Dec. 9, 2022, granted, now 11,747,348.
Application 18/064,233 is a continuation in part of application No. PCT/KR2021/018280, filed on Dec. 3, 2021.
Claims priority of application No. 10-2021-0128520 (KR), filed on Sep. 29, 2021.
Prior Publication US 2023/0375573 A1, Nov. 23, 2023
Int. Cl. G01N 33/49 (2006.01); B01L 3/00 (2006.01); G01N 33/72 (2006.01); G01N 33/80 (2006.01)
CPC G01N 33/726 (2013.01) [B01L 3/502715 (2013.01); G01N 33/49 (2013.01); G01N 33/723 (2013.01); G01N 33/80 (2013.01); B01L 2200/027 (2013.01); B01L 2200/10 (2013.01); B01L 2200/14 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/087 (2013.01); B01L 2400/0403 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method of operating a glycated hemoglobin level measuring system, comprising:
communicating an input signal (1) through a first pair of electrodes and across a first detection region, and (2) through a second pair of electrodes and across a second detection region;
detecting a first time based on a change in the input signal communicated across the first detection region, wherein the first time represents a red blood cell positioned at least partially within the first detection region;
detecting a second time based on a change in the input signal communicated across the second detection region, wherein the second time represents the red blood cell positioned at least partially within the second detection region;
calculating a speed measure based on the first and second times, wherein the speed measure represents the red blood cell traversing across at least portions of the first and second detection regions; and
determining a glycated hemoglobin level for the red blood cell based on the calculated speed measure.