US 12,013,401 B2
Radical dosimetry methods for in vivo hydroxyl radical protein foot-printing
Scot Randy Weinberger, Montara, CA (US); Ronald Carl Orlando, Athens, GA (US); Joshua Shane Sharp, Oxford, MS (US); Robert Wallace Egan, Reno, NV (US); and Jeffrey Jonathan Persoff, San Jose, CA (US)
Assigned to GENNEXT TECHNOLOGIES, INC., Half Moon Bay, CA (US)
Filed by GenNext Technologies, Inc., Half Moon Bay, CA (US)
Filed on May 2, 2023, as Appl. No. 18/142,538.
Application 18/142,538 is a continuation of application No. 17/168,472, filed on Feb. 5, 2021.
Application 17/168,472 is a continuation in part of application No. PCT/US2020/012430, filed on Jan. 6, 2020.
Application 17/168,472 is a continuation in part of application No. PCT/US2019/057059, filed on Oct. 18, 2019.
Application PCT/US2020/012430 is a continuation in part of application No. 16/316,006, filed on Jan. 7, 2019, granted, now 10,816,468, issued on Oct. 27, 2020.
Application PCT/US2019/057059 is a continuation in part of application No. 16/316,006, granted, now 10,816,468, issued on Oct. 27, 2020, previously published as PCT/US2018/034682, filed on May 25, 2018.
Claims priority of provisional application 63/128,439, filed on Dec. 21, 2020.
Claims priority of provisional application 62/788,219, filed on Jan. 4, 2019.
Claims priority of provisional application 62/747,247, filed on Oct. 18, 2018.
Claims priority of provisional application 62/511,571, filed on May 26, 2017.
Prior Publication US 2023/0296615 A1, Sep. 21, 2023
Int. Cl. G01N 33/68 (2006.01); C23C 18/14 (2006.01); G01N 21/59 (2006.01); G01N 21/63 (2006.01); G01N 21/64 (2006.01); H01J 49/00 (2006.01)
CPC G01N 33/6803 (2013.01) [C23C 18/14 (2013.01); G01N 21/59 (2013.01); G01N 21/631 (2013.01); G01N 21/6428 (2013.01); H01J 49/0036 (2013.01); G01N 2021/6439 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An analysis system comprising:
a molecular separation device configured for producing a compound of interest;
a micro-fluidic mixer configured to mix the compound of interest with a photo-reactive reagent to form a photo-reactive reagent mixture;
a flash photolysis system configured for irradiating a sample containing the photo-reactive reagent mixture;
a photolysis cell in optical communication with the flash photolysis system and being configured to receive the sample;
a radical dosimeter configured for irradiating the sample and detecting photometric absorbance of the sample; and
a feed-back closed-loop control circuit configured to control a spectral irradiance of the flash photolysis system in accordance with an absorbance change measured by the radical dosimeter.