US 12,013,343 B2
Aldehyde detection and analysis using surface-enhanced Raman spectroscopy
Mark Charles Peterman, Fremont, CA (US)
Assigned to OndaVia, Inc., Hayward, CA (US)
Filed by OndaVia, Inc., Hayward, CA (US)
Filed on Apr. 9, 2021, as Appl. No. 17/226,884.
Application 17/226,884 is a continuation of application No. 16/298,362, filed on Mar. 11, 2019, granted, now 11,002,682.
Claims priority of provisional application 62/641,529, filed on Mar. 12, 2018.
Prior Publication US 2021/0239619 A1, Aug. 5, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/65 (2006.01); G01N 1/38 (2006.01); G01N 1/44 (2006.01); G01N 21/78 (2006.01); G01N 33/18 (2006.01)
CPC G01N 21/658 (2013.01) [G01N 1/38 (2013.01); G01N 1/44 (2013.01); G01N 21/78 (2013.01); G01N 33/1826 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method of measuring an amount of an analyte in water, the water containing the analyte and a first amount of a compound reactive with a colorimetric dye, the method comprising the steps of:
obtaining a first sample of the water of a known volume;
mixing a known amount of an isotopologue with the first sample;
mixing the colorimetric dye with the first sample;
treating the analyte to form a second amount of the compound reactive with the colorimetric dye after binding the first amount of the compound reactive with the colorimetric dye to form an adduct to eliminate interference caused by the first amount of the compound reactive with the colorimetric dye;
mixing Raman-scattering nanoparticles with the first sample to produce a mixture;
producing a Raman spectrum of the mixture; and,
performing a ratiometric analysis of peaks or bands within the Raman spectrum corresponding to a reaction product of the colorimetric dye and the second amount of the compound reactive with the colorimetric dye and the isotopologue to quantify the analyte,
wherein the analyte is an aldehyde.