	US 12,012,634 B2
	Methods for diagnosing, prognosing, and treating parkinson's disease or parkinsonism
Eli Hatchwell, Winchester (GB); and Peggy S. Eis, Fitchburg, WI (US)
Assigned to POPULATION BIO, INC., New York, NY (US)
Filed by Population Bio, Inc., New York, NY (US)
Filed on Apr. 12, 2021, as Appl. No. 17/228,440.
Application 17/228,440 is a division of application No. 15/945,577, filed on Apr. 4, 2018, granted, now 11,008,614.
Application 15/945,577 is a continuation of application No. 14/026,642, filed on Sep. 13, 2013, granted, now 9,976,180, issued on May 22, 2018.
Claims priority of provisional application 61/743,919, filed on Sep. 14, 2012.
Prior Publication US 2023/0020697 A1, Jan. 19, 2023
Int. Cl. C12Q 1/6883 (2018.01); C12Q 1/6874 (2018.01); G01N 33/68 (2006.01)

CPC C12Q 1/6883 (2013.01) [C12Q 1/6874 (2013.01); G01N 33/6896 (2013.01); C12Q 2537/16 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01); G01N 2500/04 (2013.01); G01N 2800/2835 (2013.01)]

22 Claims

1. A method comprising:

(a) (i) hybridizing a nucleic acid probe to a polynucleic acid from a human subject by nucleic acid hybridization or microarray analysis, or

(a) (ii) synthesizing a nucleic acid product from a polynucleic acid from a human subject by PCR or sequencing, wherein the human subject has parkinsonism, Parkinson's Disease or symptoms of Parkinson's Disease; and

(b) detecting a genetic variation by the nucleic acid hybridization, microarray analysis, PCR or sequencing, wherein the genetic variation is a copy number variation (CNV) that is a loss of SEQ ID NO: 213, and the complement thereof.