US 12,012,416 B2
Compositions and methods for treating atopic dermatitis
Ratan K Chaudhuri, Lincoln Park, NJ (US)
Assigned to Sytheon Ltd, Boonton, NJ (US)
Filed by Sytheon Ltd, Boonton, NJ (US)
Filed on Apr. 25, 2022, as Appl. No. 17/728,876.
Application 17/728,876 is a division of application No. 16/791,732, filed on Feb. 14, 2020, granted, now 11,312,725.
Application 16/791,732 is a continuation of application No. 15/277,990, filed on Sep. 27, 2016, granted, now 10,597,402, issued on Mar. 24, 2020.
Application 15/277,990 is a continuation in part of application No. 15/081,898, filed on Mar. 27, 2016, granted, now 9,636,321, issued on May 2, 2017.
Claims priority of provisional application 62/378,217, filed on Aug. 23, 2016.
Claims priority of provisional application 62/139,619, filed on Mar. 27, 2015.
Prior Publication US 2022/0251103 A1, Aug. 11, 2022
Int. Cl. C07D 493/04 (2006.01); A61K 8/49 (2006.01); A61K 9/00 (2006.01); A61K 31/34 (2006.01); A61K 45/06 (2006.01); A61Q 17/04 (2006.01); A61Q 19/00 (2006.01); A61Q 19/08 (2006.01)
CPC C07D 493/04 (2013.01) [A61K 8/4973 (2013.01); A61K 9/0014 (2013.01); A61K 9/0053 (2013.01); A61K 31/34 (2013.01); A61K 45/06 (2013.01); A61Q 17/04 (2013.01); A61Q 19/007 (2013.01); A61Q 19/08 (2013.01); A61K 2800/74 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A method of improving, repairing and/or rejuvenating barrier function in the skin comprising applying an efficacious amount of a topical skin treatment composition to those areas of the skin for which such improvement, repair and/or rejuvenation is desired, said topical skin treatment composition comprising:
a) an isohexide according to Structure 1

OG Complex Work Unit Chemistry
wherein R1 and R2, which are the same or different, are independently selected from H and a C15 to C19 unsaturated n-alkyl carboxylate group, provided that both R1 and R2 are not hydrogen, alone or in combination with
b) one or more additional isohexides according to Structure 1 wherein R1 and R2 which are the same or different, are independently selected from H and a C15 to C19 saturated or unsaturated n-alkyl carboxylate group, provided that both R1 and R2 are not hydrogen and the isohexide is a different isomer from that of isohexide (a) or at least one of R1 and R2, is different from the R1 and R2 of isohexide (a), or both, or in combination with
c) one or more isohexides corresponding to Structure 5

OG Complex Work Unit Chemistry
wherein R4 and R5 are the same or different and are independently selected from H and saturated or unsaturated n-alkyl carboxylate groups provided that the saturated and/or unsaturated n-alkyl carboxylate groups are other than saturated and/or unsaturated n-alkyl carboxylate groups of 15 to 19 carbon atoms and provided that both R4 and R5 are not H, or in combination with
d) both (b) and (c); provided that when isohexide (c) is present at least 50 mole % of the isohexides are according to Structure 1: the carbon number for the saturated and/or unsaturated n-alkyl carboxylate groups referring the number of carbon atoms of the group excluding the carboxylate carbon.