US 12,012,338 B2
Zirconium-based cluster as a dentin tubule occlusion agent
Viktor Dubovoy, Cresskill, NJ (US); Irene Petrou, Parsippany, NJ (US); and Long Pan, Somerset, NJ (US)
Assigned to Colgate-Palmolive Company, New York, NY (US)
Filed by Colgate-Palmolive Company, New York, NY (US)
Filed on Dec. 11, 2018, as Appl. No. 16/216,262.
Claims priority of provisional application 62/598,508, filed on Dec. 14, 2017.
Prior Publication US 2019/0185339 A1, Jun. 20, 2019
Int. Cl. C01G 25/04 (2006.01); A61K 8/21 (2006.01); A61K 8/28 (2006.01); A61K 8/44 (2006.01); A61Q 11/00 (2006.01); C01F 5/10 (2006.01); C01G 25/00 (2006.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01)
CPC C01G 25/04 (2013.01) [A61K 8/21 (2013.01); A61K 8/28 (2013.01); A61K 8/44 (2013.01); A61Q 11/00 (2013.01); C01F 5/10 (2013.01); C01G 25/00 (2013.01); A61K 2800/413 (2013.01); A61K 2800/805 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C01P 2002/87 (2013.01); C01P 2004/64 (2013.01)] 7 Claims
OG exemplary drawing
 
1. An oral care composition comprising a zirconium oxychloride cluster consisting of:
a. zirconium oxychloride; and
b. a basic amino acid;
wherein the cluster has a radius of gyration of from 0.5 nm to 50 nm, wherein the cluster occludes dentin tubules effectively, and wherein the composition is selected from a dentifrice, toothpaste, tooth powder, or mouthwash.