US 12,011,716 B2
Peristaltic pumping of fluids and associated methods, systems, and devices
Jonathan M. Rothberg, Miami Beach, FL (US); Jonathan C. Schultz, Guilford, CT (US); John H. Leamon, Stonington, CT (US); Todd Roswech, Ivoryton, CT (US); and Xiaoxiao Ma, Branford, CT (US)
Assigned to Quantum-Si Incorporated, Guilford, CT (US)
Filed by Quantum-Si Incorporated, Guilford, CT (US)
Filed on Oct. 28, 2020, as Appl. No. 17/083,106.
Claims priority of provisional application 62/927,385, filed on Oct. 29, 2019.
Prior Publication US 2021/0121874 A1, Apr. 29, 2021
Int. Cl. G01N 33/68 (2006.01); A01N 1/02 (2006.01); B01L 3/00 (2006.01); C07C 309/65 (2006.01); C07C 309/73 (2006.01); F04B 43/12 (2006.01); G01N 1/40 (2006.01); G01N 21/33 (2006.01); G01N 21/64 (2006.01); G01N 33/52 (2006.01); G01N 35/10 (2006.01)
CPC B01L 3/50273 (2013.01) [F04B 43/1223 (2013.01); G01N 35/1009 (2013.01); B01L 2200/027 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/123 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A peristaltic pump, comprising:
(i) a cartridge, comprising:
a base layer having a surface comprising channels, wherein at least a portion of at least some of the channels:
have a substantially triangularly-shaped cross-section having a single vertex at a base of the channel and having two other vertices at the surface of the base layer; and
have a surface layer, comprising an elastomer, configured to substantially seal off a surface opening of the channel;
(ii) a roller configured to engage at least a portion of the surface layer;
(iii) a crank-and-rocker mechanism connected to the roller by a connecting arm;
(iv) a roller arm configured so as to join the roller to the connecting arm; and
(v) a hinge configured so as to join the roller arm to the connecting arm, wherein the hinge comprises a spring.