US 12,011,499 B2
Peptides and compositions for use in cosmetics
Ariadna Grau-Campistany, Barcelona (ES); Silvia Pastor, Alicante (ES); Patricia Carulla, Barcelona (ES); and Juan Carlos Escudero, Barcelona (ES)
Assigned to LIPOTRUE, S.L., Gava (ES)
Appl. No. 17/297,749
Filed by LIPOTRUE, S.L., Gava (ES)
PCT Filed Jan. 3, 2020, PCT No. PCT/EP2020/050070
§ 371(c)(1), (2) Date May 27, 2021,
PCT Pub. No. WO2020/144109, PCT Pub. Date Jul. 16, 2020.
Prior Publication US 2022/0062145 A1, Mar. 3, 2022
Int. Cl. A61K 38/00 (2006.01); A61K 8/64 (2006.01); A61Q 19/08 (2006.01); C07K 14/47 (2006.01)
CPC A61K 8/64 (2013.01) [A61Q 19/08 (2013.01); C07K 14/47 (2013.01)] 12 Claims
 
1. A peptide of formula (I):
R1—(X)m-AA1-AA2-AA3-AA4-AA5-(Y)n—R2   (I)
their cosmetically acceptable isomers, salts, solvates and/or derivatives and mixtures thereof, wherein:
X is Ala;
AA1 is Leu;
AA2 is His;
AA3 is Lys;
AA4 is Val;
AA5 is Lys;
Y is Val;
n and m are selected independently of each other from 0 and 1;
R1 is selected from the group consisting of substituted or unsubstituted non-cyclic aliphatic, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO— wherein R5 is selected from the group formed by substituted or unsubstituted C1-C24 alkyl radical, substituted or unsubstituted C2-C24 alkenyl, substituted or unsubstituted C2-C24 alkynyl, substituted or unsubstituted C3-C24 cycloalkyl, substituted or unsubstituted C5-C24 cycloalkenyl, substituted or unsubstituted C8-C24 cycloalkynyl, substituted or unsubstituted C6-C30 aryl, substituted or unsubstituted C7-C24 aralkyl, substituted or unsubstituted heterocyclyl ring of 3 to 10 members, and substituted or unsubstituted heteroarylalkyl of 2 to 24 carbon atoms and 1 to 3 atoms other than carbon and an alkyl chain of 1 to 6 carbon atoms and
R2 is selected from the group consisting of —NR3R4—, —OR3 and —SR3—, wherein R3 and R4 are independently selected from H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl.